About the programme
The vision and overarching aim of the Mistra SafeChem programme will be fulfilled by a broad research programme focusing on the development of tools, processes and methods with the specific objectives to:
- Develop, test and evaluate innovative industrial production processes for non-hazardous molecules involving enzyme catalysis, and minimal waste processes.
- Develop and apply a robust framework for early prediction and verification of hazardous properties of new molecules or materials using in-silico predictive models, in-vitro tools and advanced chemical/biological analytical methods.
- Develop and apply improved methods for life cycle assessment incorporating hazardous properties of molecules and materials and risks for exposure along the full value chain.
- Conduct a series of case studies where specific design, production and recycling processes, in different levels of the value chain and representing a range of applications, will be evaluated.
- Develop a vision and agenda for expansion and implementation of the Mistra SafeChem concepts into Swedish chemical industry.
- Initiate the establishment of a permanent platform for Green Chemistry Sweden – where research, innovations and collaborative efforts on safe and sustainable chemical industry can be further developed involving industry, authorities, academia and institutes.
Work packages in Mistra SafeChem
WP1: Management and communication
- Programme coordination
Administration, coordination, planning, organise and chair meetings, follow-up work in the WP:s, contact with Mistra
Website, newsletters, social media, press releases, annual report
WP2: A vision and agenda for green and sustainable chemistry
- Define green and sustainable chemistry
- Markets and policy making – opportunities and obstacles
- Legal framework – novel evaluation criteria
- Compilation of programme results vs state-of-the-art
- Develop an agenda for green chemistry
- Competence development and education
WP3: Hazard and risk screening – early warning and proactivity
Ian Cotgreave, RISE, and Magnus Breitholtz, SU
To provide a fit for purpose screening framework (risk assessment) by combination of
- In-silico (computational)
- In-vitro (cells and organisms)
- Bioanalytical methods
- ”Exposome” - Evaluate (multiple) exposures
- Environmental fate (biodegradation, bioaccumulation, adsorption/desorption, etc)
WP4: Materials Management and Design
- Develop cutting-edge green chemistry processes
- Design catalytic processes towards zero waste
- Immobilize metal catalysts to crystalline nanocellulose (CNC) and study reactions
- Study synthesis of organic building blocks using heterogeneous metal-catalysts
- Study enzyme-catalysis for functionalization of cellulose to reduce byproducts
- Tailor-make green chemical processes for fine particle recovery and reuse
- Catalytic fractionation of forest residues and recycled textiles to generate materials and chemicals
WP5: Life Cycle Management
Hanna Holmquist, IVL, and Anna-Karin Hellström, RISE IVF
- Develop and provide a life cycle-based tool for high throughput Alternatives Assessment
- Develop a model fit-for-LCA-purpose for estimation of near-field human exposure for different product application contexts
- Provide ProScale/EcoScale and UseTox LCIA characterization factors for human toxicity and ecotoxicity for all case study relevant chemicals (WP6)
- Build a database compiling relevant information from case studies (WP6)
- Deliver guidelines and training o application of life cycle approaches
WP6: Case studies
Dämien Johann Bolinius and Anton Fagerström, IVL, and Lisa Skedung, RISE
- Transform industrial challenges into cases fit for the programme and evaluation of the tools
- Apply to different contexts:
- Different value chains, different parts e.g: design/production, use in industry or products, waste/recyling
- Identification of potentially hazardous substances
- Risks for exposure during product use
- Identification of candidates for substitution
- Identification of by-products from processes in waste streams and recipients
- Open for inclusion of more case studies and/or new industry partners.
This programme is funded by: